College Football 25 has 134 teams, each with unique players and different offensive and defensive playbooks, and these are the very best plays you should run.
If you’re coming to NCAA 25 from the Madden franchise there may be an overwhelming amount of choice. Madden only features 32 teams in comparison, and RPO and other option plays add an extra layer to College Football 25’s playbooks.
Finding the best offense and defense playbook in College Football 25 ultimately comes down to personal preference and playstyle, but some plays are still more effective than others.
Best defensive playbooks in NCAA 25
Blocking in College Football 25 is subpar at best. With that in mind, we believe that the 3-3-5 defensive set is the best option because of its superior blitzing plays that regularly put pressure on the quarterback.
For players who are scared to have their blitz exposed, the 4-2-5 provides more balanced option and several secondary plays that safely covers the entire field.
3. 3-3-5
3-3 Stack has several plays that pressure the quarterback and force opponents to get the ball out fast before getting sacked. This is why we’d consider it one of the best defense playbooks in NCAA 25.
Offensive lines in College Football 25 aren’t that strong, so if your secondary does its job, you should get plenty of stops.
2. 3-3-5 Tite
If you are a fan of blitzing, Penny in the 3-3-5 formation provides plenty of great plays for getting after the quarterback.
Blitzing isn’t always the most effective in College Football 25, so don’t always expect results. But there are still plenty of scenarios where you will want to turn up the heat and make your opponent react quickly.
1. 4-2-5
Over G is one of the best defensive play options in College Football 25, as there is a four-man rush to blitz and deal with most run plays.
Additionally, the secondary in this play covers everything in the middle of the field, making it difficult for offenses to complete simple passes.
Best offensive playbooks in College Football 25
Arizona and Kansas State have the two best playbooks in College Football 25, but it all depends on what you are looking for. If you want to air it out and have dominant receivers, you will want to use the Arizona playbook.
However, if you want to ground and pound and focus on establishing an excellent run game, you will find more success with the Kansas State playbook, which has versatile running plays for running backs and mobile quarterbacks.
1. Arizona
16 Shotgun sets give players plenty of different offensive options. There is just about every pass variation you could imagine in this playbook, and it will be a nightmare for opposing defenses trying to adjust.
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2. Kansas State
Kansas State has the rare luxury of having an elite running back and mobile quarterback capable of running laps around a defense. As such, the playbook features a wide array of running back and quarterback run plays capable of tearing defenses apart and wearing down the defensive line.
3. Multiple
Multiple provides a little bit of everything making it one of the best offense playbooks in NCAA 25. Every formation on this list is available in multiple, including Trips TE, which is considered one of the best formations in College Football 25.
You can’t go wrong with multiple as players get to try out all of the best options.
4. Alabama
Bunch TE is similar to a regular bunch formation but features one tight end and two wide receivers instead of three.
This formation is powerful because the tight end runs routes that are extremely hard to cover on the left side of the field.
5. Georgia
Meanwhile, bunch formation features two receivers and one tight end on one side of the field. A tight end instead of a wide receiver creates more opportunities to run with an added blocker.
This formation makes it easy for the quarterback to follow simple routes and favors quick passing.
6. Oregon
Like Madden, the Trips formation has numerous overpowered plays. Three wide receivers on one side of the field create matchup mismatches as defensive players try to stay with their assignment.
In addition, players can use the new hot route feature and have another receiver either pull away another defender or run across to run across the field and cause more mayhem and confusion.
7. Air Force
Flexbone is one of the most exciting formations in college football. It’s unpopular in the NFL, but the triple option emphasizes a strong run game.
Quarterbacks can either run the ball themselves or pitch it to a running back trailing behind them. In addition, the playbook also features several pitches as a wide receiver will run across the line and take it themselves. For those who love to rush, this is the formation for you.
That’s are the best offense and defense playbooks in College Football 25! For more on the game, check out the best pipelines, how to kick, how to recruit in Dynasty mode, and the best settings to use.